Atenolol 50mg half life

The second one is the extended release version. I was taking 50 mg a day in both cases. The only thing that affected me was a slight feeling of dizziness at times and some mental fatigue. Read More Metoprolol has a rather short half life of approximately 6 hours, so in 24 hours, 50mg is nearly completely metabolized. This type should be taken twice a day. If you took the Tartrate version once a day, then the hills a valleys are smoothed out, so you have a reasonably even dosage in you system throughout the day.

Experimental The risk or severity of adverse effects can be increased when Atenolol is combined with Hydralazine. Approved The risk or severity of adverse effects can be increased when Atenolol is combined with Hydrochlorothiazide.

Approved, Vet Approved The serum concentration of Hydrocortisone can be increased when it is combined with Atenolol. Approved, Vet Approved Atenolol may increase the hypotensive activities of Hydroflumethiazide. Approved The metabolism of Atenolol can be decreased when combined with Hydroxychloroquine. Approved The serum concentration of Ibuprofen can be increased when it is combined with Atenolol. Approved Ibuproxam may decrease the antihypertensive activities of Atenolol. Withdrawn Icatibant may decrease the antihypertensive activities of Atenolol.

Approved The serum concentration of Idelalisib can be increased when it is combined with Atenolol. Approved Iloprost may increase the hypotensive activities of Atenolol. Approved, Investigational The serum concentration of Imatinib can be increased when it is combined with Atenolol. Approved The risk or severity of adverse effects can be increased when Imidapril is combined with Atenolol.

Investigational Imidazole salicylate may decrease the antihypertensive activities of Atenolol. Experimental The serum concentration of Imipramine can be increased when it is combined with Atenolol.

Approved The serum concentration of Indacaterol can be increased when it is combined with Atenolol. Approved The serum concentration of Atenolol can be increased when it is combined with Indalpine.

Investigational, Withdrawn The risk or severity of adverse effects can be increased when Atenolol is combined with Indapamide. Approved Atenolol may increase the hypotensive activities of Indenolol. Withdrawn The serum concentration of Atenolol can be decreased when it is combined with Indinavir. Approved Indobufen may decrease the antihypertensive activities of Atenolol. Investigational The serum concentration of Atenolol can be increased when it is combined with Indomethacin. Approved, Investigational Indoprofen may decrease the antihypertensive activities of Atenolol.

Withdrawn Atenolol may increase the orthostatic hypotensive activities of Indoramin. Withdrawn The serum concentration of Inotuzumab ozogamicin can be increased when it is combined with Atenolol. Approved Atenolol may increase the hypoglycemic activities of Insulin Pork. Approved Ipidacrine may increase the bradycardic activities of Atenolol. Experimental Iproclozide may increase the hypotensive activities of Atenolol.

Withdrawn Iproniazid may increase the hypotensive activities of Atenolol. Withdrawn The risk or severity of adverse effects can be increased when Atenolol is combined with Irbesartan. Approved, Investigational The serum concentration of Irinotecan can be increased when it is combined with Atenolol. Approved, Investigational The serum concentration of Atenolol can be increased when it is combined with Isavuconazonium. Approved, Investigational Isocarboxazid may increase the hypotensive activities of Atenolol.

Approved Atenolol may decrease the bronchodilatory activities of Isoetarine. Approved The risk or severity of adverse effects can be increased when Isoflurane is combined with Atenolol. Approved, Vet Approved Isoflurophate may increase the bradycardic activities of Atenolol. Approved, Withdrawn Atenolol may decrease the bronchodilatory activities of Isoprenaline. Approved The risk or severity of adverse effects can be increased when Atenolol is combined with Isosorbide Dinitrate.

Approved The risk or severity of adverse effects can be increased when Atenolol is combined with Isosorbide Mononitrate. Approved Isoxicam may decrease the antihypertensive activities of Atenolol. Withdrawn The risk or severity of adverse effects can be increased when Atenolol is combined with Isoxsuprine. Approved, Withdrawn The risk or severity of adverse effects can be increased when Isradipine is combined with Atenolol. Approved The serum concentration of Atenolol can be increased when it is combined with Itraconazole.

Approved, Investigational Atenolol may increase the bradycardic activities of Ivabradine. Approved The serum concentration of Atenolol can be increased when it is combined with Ivacaftor. Approved The serum concentration of Ivermectin can be increased when it is combined with Atenolol. Approved, Vet Approved Kebuzone may decrease the antihypertensive activities of Atenolol. Experimental The serum concentration of Atenolol can be increased when it is combined with Ketamine.

Approved, Vet Approved Ketanserin may increase the hypotensive activities of Atenolol. Investigational The serum concentration of Ketazolam can be increased when it is combined with Atenolol.

Approved The serum concentration of Atenolol can be increased when it is combined with Ketoconazole. Approved, Investigational Ketoprofen may decrease the antihypertensive activities of Atenolol. Approved, Vet Approved Ketorolac may decrease the antihypertensive activities of Atenolol. Approved Atenolol may increase the orthostatic hypotensive activities of Labetalol. Approved Atenolol may increase the hypotensive activities of Lacidipine.

Approved Atenolol may increase the atrioventricular blocking AV block activities of Lacosamide. Approved The serum concentration of Lamivudine can be increased when it is combined with Atenolol. Approved, Investigational The serum concentration of Lamotrigine can be increased when it is combined with Atenolol.

Approved, Investigational Atenolol may increase the bradycardic activities of Lanatoside C. Experimental Atenolol may increase the bradycardic activities of Lanreotide. Approved The serum concentration of Atenolol can be increased when it is combined with Lansoprazole.

Approved, Investigational The serum concentration of Atenolol can be increased when it is combined with Lapatinib. Approved, Investigational Atenolol may increase the hypotensive activities of Latanoprost. Approved, Investigational The serum concentration of Ledipasvir can be increased when it is combined with Atenolol. Approved Leflunomide may decrease the antihypertensive activities of Atenolol. Approved, Investigational The serum concentration of Lenalidomide can be increased when it is combined with Atenolol.

Approved The serum concentration of Lenvatinib can be increased when it is combined with Atenolol. Approved Atenolol may increase the hypotensive activities of Lercanidipine. Approved, Investigational The serum concentration of Levetiracetam can be increased when it is combined with Atenolol.

Approved, Investigational The risk or severity of adverse effects can be increased when Atenolol is combined with Levobunolol. Approved The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Atenolol. Approved Atenolol may increase the orthostatic hypotensive activities of Levodopa. Approved The serum concentration of Levofloxacin can be increased when it is combined with Atenolol.

Approved, Investigational The serum concentration of Levomilnacipran can be increased when it is combined with Atenolol. Approved Levonordefrin may increase the atrioventricular blocking AV block activities of Atenolol. Approved Atenolol may decrease the bronchodilatory activities of Levosalbutamol.

Approved The risk or severity of adverse effects can be increased when Levosimendan is combined with Atenolol. Approved, Investigational The serum concentration of Atenolol can be decreased when it is combined with Levothyroxine. Approved The serum concentration of Linagliptin can be increased when it is combined with Atenolol.

Approved Atenolol may increase the hypotensive activities of Linsidomine. Experimental The serum concentration of Atenolol can be decreased when it is combined with Liothyronine.

Approved, Vet Approved The serum concentration of Atenolol can be decreased when it is combined with Liotrix. Approved The risk or severity of adverse effects can be increased when Atenolol is combined with Lisinopril. Approved, Investigational Lisofylline may decrease the antihypertensive activities of Atenolol.

Investigational The risk or severity of adverse effects can be increased when Atenolol is combined with Lobeline. Investigational Lofexidine may increase the atrioventricular blocking AV block activities of Atenolol.

Approved, Investigational The serum concentration of Atenolol can be increased when it is combined with Lomitapide. Approved Lonazolac may decrease the antihypertensive activities of Atenolol. Experimental The serum concentration of Loperamide can be increased when it is combined with Atenolol.

Approved The serum concentration of Atenolol can be increased when it is combined with Lopinavir. Approved The serum concentration of Atenolol can be increased when it is combined with Loratadine. Approved Lornoxicam may decrease the antihypertensive activities of Atenolol. Approved The risk or severity of adverse effects can be increased when Atenolol is combined with Losartan. Approved The serum concentration of Atenolol can be increased when it is combined with Lovastatin.

Approved, Investigational Loxoprofen may decrease the antihypertensive activities of Atenolol. Approved Atenolol may increase the bradycardic activities of Lucinactant. Approved The serum concentration of Atenolol can be decreased when it is combined with Lumacaftor. Approved Lumiracoxib may decrease the antihypertensive activities of Atenolol. Approved, Investigational Atenolol may increase the hypotensive activities of Macitentan. Approved Magnesium salicylate may decrease the antihypertensive activities of Atenolol.

Approved Malathion may increase the bradycardic activities of Atenolol. Approved, Investigational Atenolol may increase the hypotensive activities of Manidipine.

Approved The risk or severity of adverse effects can be increased when Atenolol is combined with Mannitol. Approved, Investigational The serum concentration of Atenolol can be increased when it is combined with Maprotiline.

Approved Masoprocol may decrease the antihypertensive activities of Atenolol. Approved Mebanazine may increase the hypotensive activities of Atenolol.

Withdrawn The serum concentration of Atenolol can be increased when it is combined with Mebendazole. Approved, Vet Approved The risk or severity of adverse effects can be increased when Atenolol is combined with Mecamylamine. Approved Meclofenamic acid may decrease the antihypertensive activities of Atenolol. Approved, Vet Approved Mefenamic acid may decrease the antihypertensive activities of Atenolol. Approved Mefloquine may increase the bradycardic activities of Atenolol.

Approved The serum concentration of Atenolol can be increased when it is combined with Megestrol acetate. Approved, Vet Approved Meloxicam may decrease the antihypertensive activities of Atenolol. Approved, Vet Approved Memantine may increase the bradycardic activities of Atenolol. Approved, Investigational The serum concentration of Mepivacaine can be increased when it is combined with Atenolol. Approved, Vet Approved The serum concentration of Atenolol can be increased when it is combined with Meprobamate.

Approved, Illicit Mesalazine may decrease the antihypertensive activities of Atenolol. Approved Mesoridazine may increase the hypotensive activities of Atenolol. Approved Atenolol may increase the hypoglycemic activities of Metahexamide. Experimental Metamizole may decrease the antihypertensive activities of Atenolol.

Withdrawn The risk or severity of adverse effects can be increased when Atenolol is combined with Methacholine. Approved The serum concentration of Atenolol can be increased when it is combined with Methadone. Approved Methamphetamine may increase the atrioventricular blocking AV block activities of Atenolol. Approved, Illicit Methanesulfonyl Fluoride may increase the bradycardic activities of Atenolol. Investigational The risk or severity of adverse effects can be increased when Atenolol is combined with Methazolamide.

Approved Methohexital may increase the hypotensive activities of Atenolol. Approved Atenolol may increase the hypotensive activities of Methoserpidine. Experimental The serum concentration of Methotrexate can be increased when it is combined with Atenolol. Approved Methotrimeprazine may increase the hypotensive activities of Atenolol.

Approved The risk or severity of adverse effects can be increased when Methyclothiazide is combined with Atenolol. Approved Methyl salicylate may increase the bradycardic activities of Atenolol.

Approved, Vet Approved The risk or severity of adverse effects can be increased when Atenolol is combined with Methyldopa. Approved Methylene blue may increase the hypotensive activities of Atenolol. Investigational Atenolol may increase the vasoconstricting activities of Methylergometrine.

Approved Methylphenidate may decrease the antihypertensive activities of Atenolol. Approved, Investigational Methylphenobarbital may increase the hypotensive activities of Atenolol. Approved The serum concentration of Methylprednisolone can be increased when it is combined with Atenolol. Approved, Vet Approved Atenolol may increase the bradycardic activities of Metildigoxin.

Experimental The risk or severity of adverse effects can be increased when Atenolol is combined with Metipranolol. Approved Metoclopramide may increase the bradycardic activities of Atenolol. Approved, Investigational The risk or severity of adverse effects can be increased when Atenolol is combined with Metolazone. Approved The risk or severity of adverse effects can be increased when Metoprolol is combined with Atenolol.

Approved, Investigational Atenolol may increase the hypotensive activities of Metyrosine. Approved The serum concentration of Atenolol can be increased when it is combined with Mibefradil. Withdrawn The serum concentration of Atenolol can be increased when it is combined with Miconazole. Approved, Investigational, Vet Approved The serum concentration of Atenolol can be decreased when it is combined with Midazolam. Approved, Illicit Atenolol may increase the bradycardic activities of Midodrine.

Approved The serum concentration of Atenolol can be decreased when it is combined with Mifepristone. Approved, Investigational The serum concentration of Atenolol can be increased when it is combined with Milnacipran.

Approved Minaprine may increase the bradycardic activities of Atenolol. Approved The risk or severity of adverse effects can be increased when Atenolol is combined with Minoxidil. Approved The serum concentration of Mirabegron can be increased when it is combined with Atenolol.

Approved Mirodenafil may increase the antihypertensive activities of Atenolol. Investigational The serum concentration of Atenolol can be increased when it is combined with Mitomycin. Approved The serum concentration of Atenolol can be decreased when it is combined with Mitoxantrone.

Approved, Investigational Mizoribine may decrease the antihypertensive activities of Atenolol. Investigational Moclobemide may increase the hypotensive activities of Atenolol.

Approved The risk or severity of adverse effects can be increased when Atenolol is combined with Moexipril. Approved Mofebutazone may decrease the antihypertensive activities of Atenolol. Experimental Molsidomine may increase the hypotensive activities of Atenolol. Approved Moricizine may increase the hypotensive activities of Atenolol. Approved, Withdrawn The serum concentration of Morphine can be increased when it is combined with Atenolol. Approved, Investigational Moxonidine may increase the atrioventricular blocking AV block activities of Atenolol.

Approved Atenolol may increase the hypotensive activities of Muzolimine. Experimental The serum concentration of Mycophenolate mofetil can be increased when it is combined with Atenolol. Approved, Investigational Mycophenolic acid may decrease the antihypertensive activities of Atenolol. Approved The risk or severity of adverse effects can be increased when Nabilone is combined with Atenolol. Approved, Investigational Nabumetone may decrease the antihypertensive activities of Atenolol.

Approved The risk or severity of adverse effects can be increased when Atenolol is combined with Nadolol. Approved Nafamostat may decrease the antihypertensive activities of Atenolol. Approved, Investigational Naftifine may decrease the antihypertensive activities of Atenolol. Atenolol Tablets, for oral administration, are available as 25 mg, 50 mg and mg tablets. Citric acid anhydrous , colloidal silicon dioxide, croscarmellose sodium, magnesium stearate, microcrystalline cellulose, povidone.

Atenolol Tablets - Clinical Pharmacology Atenolol is a beta1-selective cardioselective beta-adrenergic receptor blocking agent without membrane stabilizing or intrinsic sympathomimetic partial agonist activities. This preferential effect is not absolute, however, and at higher doses, atenolol inhibits beta2- adrenoreceptors, chiefly located in the bronchial and vascular musculature. Pharmacokinetics and Metabolism In man, absorption of an oral dose is rapid and consistent but incomplete.

Peak blood levels are reached between two 2 and four 4 hours after ingestion. Unlike propranolol or metoprolol, but like nadolol, atenolol undergoes little or no metabolism by the liver, and the absorbed portion is eliminated primarily by renal excretion. This kinetic profile results in relatively consistent plasma drug levels with about a fourfold interpatient variation. The elimination half-life of oral atenolol is approximately 6 to 7 hours, and there is no alteration of the kinetic profile of the drug by chronic administration.

Following intravenous administration, peak plasma levels are reached within 5 minutes. Declines from peak levels are rapid 5 to 10 fold during the first 7 hours; thereafter, plasma levels decay with a half-life similar to that of orally administered drug.

Following oral doses of 50 mg or mg, both beta-blocking and antihypertensive effects persist for at least 24 hours. Pharmacodynamics In standard animal or human pharmacological tests, beta-adrenoreceptor blocking activity of atenolol has been demonstrated by: Slideshow Love Your Dad?

Here's 10 Heart-Healthy Gifts For Father's Day A significant beta-blocking effect of atenolol, as measured by reduction of exercise tachycardia, is apparent within one hour following oral administration of a single dose. This effect is maximal at about 2 to 4 hours, and persists for at least 24 hours.

Maximum reduction in exercise tachycardia occurs within 5 minutes of an intravenous dose. For both orally and intravenously administered drug, the duration of action is dose related and also bears a linear relationship to the logarithm of plasma atenolol concentration. The effect on exercise tachycardia of a single 10 mg intravenous dose is largely dissipated by 12 hours, whereas beta-blocking activity of single oral doses of 50 mg and mg is still evident beyond 24 hours following administration.

However, as has been shown for all beta-blocking agents, the antihypertensive effect does not appear to be related to plasma level. In normal subjects, the beta1 selectivity of atenolol has been shown by its reduced ability to reverse the beta2-mediated vasodilating effect of isoproterenol as compared to equivalent betab-locking doses of propranolol.

In asthmatic patients, a dose of atenolol producing a greater effect on resting heart rate than propranolol resulted in much less increase in airway resistance. In a placebo controlled comparison of approximately equipotent oral doses of several beta blockers, atenolol produced a significantly smaller decrease of FEV1 than nonselective beta blockers such as propranolol and, unlike those agents, did not inhibit bronchodilation in response to isoproterenol.

Consistent with its negative chronotropic effect due to beta blockade of the SA node, atenolol increases sinus cycle length and sinus node recovery time. Conduction in the AV node is also prolonged. Therefore, when discontinuation of atenolol is planned in patients with angina pectoris, the dosage should be gradually reduced over a period of about 2 weeks and the patient should be carefully observed and advised to limit physical activity to a minimum.

The same frequency of administration should be maintained. In situations of greater urgency, atenolol should be discontinued stepwise over a shorter time and under closer observation. If angina markedly worsens or acute coronary insufficiency develops, it is recommended that treatment with atenolol be reinstituted promptly, at least temporarily. Various skin rashes and conjunctival xerosis have been reported with b-blockers, including atenolol.

A severe syndrome oculomucocutaneous syndrome whose signs include conjunctivitis sicca and psoriasiform rashes, otitis, and sclerosing serositis has occurred with the chronic use of one b-adrenergic blocking agent practolol. This syndrome has not been observed with atenolol or any other such agent. However, physicians should be alert to the possibility of such reactions and should discontinue treatment in the event that they occur. Atenolol, therefore, should only be used in these patients with the utmost care.

Severe sinus bradycardia may occur with the use of atenolol from unopposed vagal activity remaining after blockade of b 1-adrenergic receptors; in such cases, dosage should be reduced. In patients with thyrotoxicosis, possible deleterious effects from long-term use of atenolol have not been adequately appraised.

Therefore, abrupt withdrawal of atenolol may be followed by an exacerbation of the symptoms of hyperthyroidism, including thyroid storm. First Degree Heart Block: Due to its negative effect on AV conduction time, atenolol should be used with caution in patients with first degree block.

Peripheral Arterial Circulatory Disorders: Atenolol may aggravate less severe peripheral arterial circulatory disorders see Contraindications. There may be increased difficulty in treating an allergic type reaction in patients on b-blockers.

In these patients, the reaction may be more severe due to pharmacologic effects of b-blockers and problems with fluid changes. Epinephrine should be administered with caution since it may not have its usual effects in the treatment of anaphylaxis. On the one hand, larger doses of epinephrine may be needed to overcome the bronchospasm, while on the other, these doses can be associated with excessive a-adrenergic stimulation with consequent hypertension, reflex bradycardia and heart block and possible potentiation of bronchospasm.

Alternatives to the use of large doses of epinephrine include vigorous supportive care such as fluids and the use of b-agonists including parenteral salbutamol or isoproterenol to overcome bronchospasm and norepinephrine to overcome hypotension.

Diabetes and Patients Subject to Hypoglycemia: Atenolol should be administered with caution to patients subject to spontaneous hypoglycemia, or to diabetic patients especially those with labile diabetes who are receiving insulin or oral hypoglycemic agents. Atenolol should be used with caution in patients with impaired renal function see Dosage. It is not advisable to withdraw b-adrenoceptor blocking drugs prior to surgery in the majority of patients.

Psoriasis may be aggravated. One of the pharmacological actions of atenolol is to reduce the heart rate.

Care should be taken when anaesthetic agents are used with atenolol. The patient should be warned to inform the anaesthetist.

Such interactions can have life-threatening consequences. It should be noted that digitalisation of patients receiving long term atenolol therapy may be necessary if congestive cardiac failure is likely to develop. This combination can be considered despite the potentiation of negative chronotropic effect of the two medicines.

Neither medicine should be administered intravenously within 48 hours of discontinuing the other.

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